Welcome to Corius

We have one goal: to provide breakthrough technologies for transforming injured skin into healthy skin.

Corius is derived from the Latin word meaning skin. Corius is a division of Medline created to help empower the surgical community to advance quality healing and enable better outcomes for patients. At the heart of our commitment are clinicians, researchers, scientists and entrepreneurs driven to discover unique mechanisms of action designed to optimize the speed and quality of healing.

Learn more about the Corius division

Hyalomatrix

Facilitate closure and help patients get back to their lives quickly.

Using the dermal regeneration properties of hyaluronic acid (HA), Hyalomatrix helps you rebuild tissue. HA is a main component of the extracellular matrix and is considered one of the key players in the tissue regeneration process.¹ Hyalomatrix puts HA’s innate tissue regeneration properties in your skilled hands, helping you bring new hope to patients and their families. It features HYAFF, an exceptionally long-lasting form of HA. HYAFF delivers HA to the wound bed in a prolonged manner, facilitating each stage of the healing process.^2-6

Gloved hands holding wound dressing

Clinical evidence

Hyalomatrix. Well-established. Well-documented.

The roles of HA, HYAFF and Hyalomatrix are supported by more than 800 peer-reviewed published papers.

750+

Exploratory research studies on hyaluronic acid

45

HYAFF technology studies

34

Hyalomatrix clinical studies

Coverage of exposed Achilles tendon

Transmetatarsal amputation

A regenerative matrix for complex lower extremity wounds with exposed bone or tendon

Limb salvage of necrotic foot

Non-healing venous leg ulcer

Published evidence

	Title	Publication	Authors	Year
1	Esterified Hyaluronic Acid Matrix in Lower Extremity Reconstruction With Exposed Tendon and Bone: A Retrospective Review	J Burn Care Res. 2020 Jul 3;41(4):828-834.	Kozusko SD, Hassouba M, Hill DM, Liu X, Dadireddy K, Velamuri SR	2020
2	Neodermis formation in full thickness wounds using an esterified hyaluronic acid matrix	Journal of Burn Care & Research 2019.	Aballay A, Hermans MHE.	2019
3	Preclinical and Clinical Studies of Hyaluronic Acid in Wound Care: A Case Series and Literature Review	Wounds 2019 Feb;31(2):41–48.	Schneider HP, Landsman	2019
4	Necrotizing Fasciitis: An Overview and 2 Illustrative Cases	Wounds 2018 Dec;17(4):295-300	Kapp DL, Rogers M, Hermans MHE	2018
5	Outcomes of an Esterified Hyaluronic Acid Matrix in the Treatment of Chronic Lower Extremity Wounds: A Case Series	Wounds 2018 Dec;30(12):367-371	Cheung T, Laidley Z, Jones J, Wu S	2018
6	Use of Hyaluronic Acid–Based Biological Bilaminar Matrix in Wound Bed Preparation: A Case Series	ePlasty 2018 Feb 22;18:e10	Simman R, Mari W, Younes S, Wilson M.	2018
7	Venous Ulcers Treated With a Hyaluronic Acid Extracellular Matrix and Compression Therapy: Interim Analysis of a Randomized Controlled Trial	Wounds 2017;29(7):E51–E54.	Alvarez OM, Makowitz L, Patel M	2017
8	Hyaluronic Acid in Inflammation and Tissue Regeneration	Wounds 2016;28(3):78-88.	Litwiniuk M, Krejner A, Grzela T.	2016
9	Limb Trauma: the use of an advanced wound care device in the treatment of full-thickness wounds	Strat Traum Limb Recon 2013;8:111-115.	Vaienti L, Marchesi A, Palitta G, Gazzola R, Parodi PC, Leone F	2013
10	Interaction between a regenerative matrix and wound bed in nonhealing ulcers: results with 16 cases	Biomed Res Int 2013; 2013:849321.	Motolese A, Vignati F, Brambilla R, Cerati M, Passi A.	2013
11	Wound Bed Preparation with a Dermal Substitute (Hyalomatrix PA) Facilitates Re-epithelialization and Healing: Results of a Multicenter, Prospective, Observational Study on Complex Chronic Ulcers (The FAST Study)	Wounds 2011;23(8):228-235.	Caravaggi C, Grigoletto F, Scuderi N.	2011
12	Hyaluronan Benzyl Ester as a Scaffold for Tissue Engineering	International Journal of Molecular Sciences 2009; 10: 2972-2985.	Vindigni V, Cortivo R, Iacobellis L, Abatangelo G, Zavan B.	2009
13	Skin pH Variations from the Acute Phase to Re-Epithelialization in Burn Patients Treated with New Materials (Burnshield, Semipermeable, Adhesive Film, Dermasilk, and Hyalomatrix). Non-invasive preliminary Experimental Clinical Trial	Annals of Burns and Fire Disasters 2008; 21(2):73-77.	Osti E.	2008

Request additional studies/pediatric studies from Medical Affairs.

Hyalomatrix® clinical support

Instructions for use | Instructions for use (Non-silicone)

References

Litwiniuk M, Krejner A, Speyrer MS, Gauto AR, Grzela T. Hyaluronic Acid in Inflammation and Tissue Regeneration. Wounds. 2016 Mar;28(3):78-88. PMID: 26978861.
Caravaggi C, Grigoletto F, Scuderi N. Wound Bed Preparation With a Dermal Substitute (Hyalomatrix® PA) Facilitates Re-epithelialization and Healing: Results of a Multicenter, Prospective, Observational Study on Complex Chronic Ulcers (The FAST Study). WOUNDS 2011;23(8):228–235. Available at: http://www.medscape.com/viewarticle/749515_1 Accessed June 18, 2018.
Voigt J, Driver VR. Hyaluronic Acid Derivatives and Their Healing Effect on Burns, Epithelial Surgical Wounds, and Chronic Wounds: a Systematic Review and Meta-Analysis of Randomized Controlled Trials. Wound Repair Regen. 2012 May-Jun;20(3):317-31. Available at: http://www.ncbi.nlm.nih.gov/pubmed/22564227 Accessed June 18, 2018.
Gravante G, Sorge R, Merone A, et al. Hyalomatrix PA in Burn Care Practice: Results From a National Retrospective Survey, 2005–2006. Ann Plast Surg. 2010;64(1):69–79.
Longinotti C. The Use of Hyaluronic Acid-Based Dressings to Treat Burns: A Review. Burn Trauma [Epub ahead of print] [cited 2014 Oct 16]. Available from: http://burnstrauma.com/temp/BurnTrauma24162-6158285_170622.pdf Accessed June 20, 2018.
Moseley R, Walker M, Waddington RJ, Chen WYJ. Comparison of the Antioxidant Properties of Wound Dressing Materials–Carboxymethylcellulose, Hyaluronan Benzyl Ester and Hyaluronan, Towards Polymorphonuclear Leukocyte-Derived Reactive Oxygen Species. Biomaterials (Impact Factor: 8.31). 05/2003; 24(9):1549-57.